CD4 and neoplasm: The enrichment analysis of the two groups displayed that the 14 genes related to cuproptosis and copper metabolism were significantly enriched in immunocytes, tumorigenesis, such as immune response, intermediate filament, B-cell proliferation, and so on (42–46) The correlation analysis of the tumor immune microenvironment revealed that the activation of cells in the high-risk group had the characteristics of “cold tumor”, such as naïve CD4 T cells, resting NK cells, and M0 macrophages.