Interestingly, overexpression of LINC00473 ameliorated depression in depressed female mice via upregulating proportion of sucrose consumed, time in open arm, and the contents of neurotransmitter including NE, DA, and 5-HT in the mouse hypothalamus, as well as upregulating immobility time and cold water immobility time. This evidence concerns the gene PDE10A and depressive symptom measurement.