Mutations of FLT3 are the most frequent genetic lesions, found in approximately 20 to 30% of newly diagnosed AML cases consisting of ITD mutations within the juxtamembrane (JM) domain and with a minor subset consisting of point mutations in the tyrosine kinase domain (TKD) [19, 21, 22]. The gene discussed is FLT3; the disease is acute myeloid leukemia.