Activation of the mutation of the receptor tyrosine kinase (RTK) c-KIT and related signaling partners has been described as an oncogenic driver in the molecular pathogenesis of various types of human malignancies, including mast cell activation disorders, gastrointestinal stromal tumors, melanomas, and acute myeloid leukemia (AML) [3–5]. This evidence concerns the gene KIT and acute myeloid leukemia.