The tumor environment releases interleukin-8 to promote the apoptosis of the local tumor neutrophils and activates neutrophils to promote tumor cell shedding from the primary tumor body, allowing them to migrate along the lung basement membrane to another alveolar cavity, resulting in STAS (Wislez et al., 2004; Wislez et al., 2007). This evidence concerns the gene CXCL8 and neoplasm.