The six hub genes were CXCL8, CXCL1, CCL3, C8A, CPB2, and LCN2. The TCGA and GTE databases revealed that the other five genes significantly differed in gene expression in lung adenocarcinoma tumors versus normal tissues, except for the CXCL1 gene (Figures 4A–F). The gene discussed is CXCL1; the disease is lung adenocarcinoma.