TP53 and cancer: Moreover, AURKA has been shown to participate in cancer-promoting processes by regulating the cell cycle and activating oncogenic signaling pathways, including p53 (Saiprasad et al., 2014; Mar et al., 2015; Vilgelm et al., 2015; Katsha et al., 2017; Wang et al., 2017; Wang-Bishop et al., 2019; Wang et al., 2021).