Regulatory factor X3 (RFX3) is associated with predisposition genes in endometrial cancer (Shivakumar et al., 2019), metastasis in BC(Legare et al., 2017), chromosomal rearrangement in B lymphocytes (Twa et al., 2015), and the promotion of cancer cell proliferation (Ham et al., 2019). Here, RFX3 is linked to endometrial cancer.