The cluster of differentiation CD8+ T cells in early recurrent hepatocellular carcinoma is characterized by killer cell lectin-like receptor B1 (KLRB1; CD161) overexpression, mainly in an innate class, low cytotoxicity, low clonal expansion state, and low expression of costimulatory and checkpoint molecules (Sun et al., 2021). The gene discussed is KLRB1; the disease is hepatocellular carcinoma.