The apoptosis of melanoma is induced by DMAS by upregulating phorbol-12-myristate-13-acetate-induced protein 1 (NOXA) (Stallinger et al., 2020), and DMAS blocks hepatocellular carcinoma cell cycle arrest in the G2 phase (Tummers et al., 2020). Here, PMAIP1 is linked to hepatocellular carcinoma.