As opposed to chemical colitis, which targets the murine colon, genetic models of intestinal pathology, including the SAMP1/YitFc model of spontaneous ileitis might provide an attractive avenue to better study Itln1 in the context of Crohn’s disease; however, a confounding factor posed by this model is that it was developed on a mixed strain background derived from AKR/J inbred mice, which encode multiple Itln genes (i.e., Itln1, -2, -4, and -6) (23, 57–59). This evidence concerns the gene ITLN1 and colitis.