Glycolytic-promoting factors including c-Myc, HIF-1, GLUT1, hexokinase (HK), pyruvate kinase (PK), phosphofructokinase (PFK), phosphoglycerate kinase 1 (PGK1), lactate dehydrogenase (LDH), and pyruvate dehydrogenase kinase isozyme 1 (PDK-1) that activated in tumor cells are described as tumor markers (80, 81). This evidence concerns the gene HK1 and neoplasm.