CDH1 and osteosarcoma: P2X7R activation causes cell migration, up-regulation of EMT-related genes, and down-regulation of epithelial cadherins (E-cadherins) in prostate, breast, and osteosarcoma cell lines, all of which are mediated through phosphoinositide 3-kinases (PI3K)/Akt phosphorylation and ERK1/2 pathways (Figure 1) (42, 43).