In a metastatic breast cancer cell line incubated with endothelial cells, P2Y2R activation enhanced intracellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) expression, resulting in increased adhesion between cancer cells and endothelial cells as well as cancer cell metastasis (45). This evidence concerns the gene P2RY2 and cancer.