Incubation of gastric or breast cancer cells with ADO increases EMT gene expression, associated with A2AR/A2BR activation and the Akt-mammalian target of rapamycin (mTOR) or adenylyl cyclase (AC)/protein kinase A (PKA)/cyclic adenosine monophosphate (cAMP) pathway (Figure 1) (49). The gene discussed is MTOR; the disease is breast cancer.