ITGAX and systemic lupus erythematosus: IgD+ cells with the features of ABCs have been reported in SLE patients and in aged female mice (23, 30, 31), while Bcl6 in B cells was not required for CD11c+ T-bet+ ABCs formation in Lymphocytic Choriomeningitis Virus (LCMV) and Influenza virus infection in mice (39).