The increase in adiposity has been associated with metabolic changes in MM cells, such as an increase in the metabolite acetyl-coA synthetase 2 (ACSS2) in MM cells, induced by adipocyte-secreted angiotensin II and driving MM growth in vitro and in vivo at least partly by enhancing the stability of the myeloma oncoprotein IRF4 (74). The gene discussed is ACSS1; the disease is Miyoshi myopathy.