TGFB1 and Autoimmunity: Tgfbr2flox/flox), they showed that deficient TGFβ signaling in B cells led to reduced lifespan of B2 B cells, expansion of B1-peritoneal B cells, elevated IgG3 responses to a weakly immunogenic antigen, generation of anti-dsDNA antibodies and overall B cell hyperresponsiveness but did not lead to overt clinical autoimmunity.