For instance, the very recent demonstration that intratumoral CD8+ T cells could recruit Tfh to the tumor microenvironment via CXCL13 secretion following TGFβ stimulation (147) or the discovery of novel immune populations, such as follicular regulatory Innate Lymphoid Cells (ILCfr), which appear to inhibit the GCR in a TGFβ-dependent manner (37). The gene discussed is TGFB1; the disease is neoplasm.