This field of research is rapidly expanding; further studies will be critical in establishing the precise mechanisms of TGFβ-mediated regulation of the GCR, which will surely inform new avenues of treatment for autoimmunity, graft rejection, allergy ... Interestingly, animal studies have previously demonstrated that αvβ8 targeting is possible to treat inflammatory disorders such as encephalitis or lung inflammation and to overcome tumor immune evasion (92, 116, 149, 150). Here, TGFB1 is linked to Autoimmunity.