CRP and autoimmune disease: In the Jansson system, minor criteria include (1) Normal blood count and good general state of health, (2) Increase of C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) (mild to moderate levels), (3) Time for more than half a year, (4) Hyperostosis, and (5) Positive family history with grade I or II relatives diagnosed by any autoimmune disease.