ACE2 and swine influenza: As the H1N1 influenza model is ACE2-receptor independent, the observed reduction in lung inflammation in the H1N1 influenza model following G921 treatment (Supplemental Figure 5) indicates an effect of G921-supplied ACE2 enzymatic activity and supports that G921 can work as a direct anti-inflammatory molecule in diseases independent of the ACE2-driven direct binding and neutralization.