APOE and Alzheimer disease: When using the age+sex+APOE4 panel alone, we calculated an AUC of 73.4% (95%CI = 0.63–0.84) for HC vs. AD (Figure 3A), AUC of 64.6% (95% CI = 0.53–0.76) for HC vs. MCI (Figure 3B) and an AUC of 66.4% (95%CI = 0.56–0.77) for MCI vs. AD (Figure 3C).