Molecular mechanism studies indicated that LDHA plays critical roles in tumor maintenance and aggravation, including promoting cancer cell proliferation, epithelial to mesenchymal transition (Jiang et al., 2016), angiogenesis (Giatromanolaki et al., 2006), cytoskeletal remodeling (Arseneault et al., 2013), cell motility, invasion and metastasis (Liu et al., 2015). Here, LDHA is linked to cancer.