Hypoxia-inducible factor-2α (HIF-2α), which is critical for tumor cells to adapt to the hypoxic microenvironment, enhances tumor stemness by elevating the expression level of stemness-associated transcriptional factors Nanog and Oct4 through classic Wnt/β-catenin signaling pathway (Zhang et al., 2017). Here, EPAS1 is linked to neoplasm.