In addition, NEAT1 regulated CSC properties including self-renew and chemo-resistance in triple-negative breast cancer and lung cancer stem cells by upregulating the expression of pluripotency regulators SOX2, CD44 molecule (CD44), and aldehyde dehydrogenase (ALDH) in a Wnt signaling dependent manner (Shin et al., 2019). Here, CD44 is linked to lung cancer.