Further analysis revealed that TRPV2 and TRPM2, TRPV4 and TRPM4, and TRPV5 and TRPV6 may also had the interaction, which indicates that the role of TRPVs and TRPMs in the development of CSCC may be the result of the joint action of multiple subunits, which also provides ideas for studying the mechanism of action of TRPV1 and TRPM5 in CSCC. Here, TRPV2 is linked to skin squamous cell carcinoma.