Thereinto, three N-glycoproteins were up-expressed in ccRCC patients, including CD97, coagulation factor c homolog, while six N-glycoproteins were down-expressed, such as haptoglobin, fibronectin, and ceruloplasmin, suggesting that urinary N-glycoproteins were related to malignancy and could be applied as noninvasive biomarkers (Ene et al., 2020). This evidence concerns the gene FN1 and nonpapillary renal cell carcinoma.