Based on the TCGA database, this study investigated the molecular mechanism affecting the initial lymphatic metastasis of COAD patients and preliminarily identified six core genes (RNU4-2, ZNF556, RNVU1-15, NSA2P6, RN7SL767P, and RN7SL473P). The gene discussed is RN7SL473P; the disease is colon adenocarcinoma.