According to the results of the network analysis, four targets with higher degrees and betweenness values, including ESR1 (degree: 411; betweenness: 0.02458607), MAPT (degree: 253; betweenness: 0.02371366), AKT1 (degree: 153; betweenness: 0.00357142), and ALB (degree: 79; betweenness: 0.00317278) were probably the key targets of DSS in the treatment of depression. Here, ESR1 is linked to major depressive disorder.