It is reported that a series of tsRNAs are responsive to sex hormones and are elevated in ER-positive BC and AR-positive prostate cancer, designating these tsRNAs as sex-hormone-dependent tRNA-derived RNAs (SHOT-RNAs) which are cleaved by ANG, forming 5′-SHOT-RNAs and 3′-SHOT-RNAs (Honda et al., 2015). This evidence concerns the gene AR and breast cancer.