It was reported that tRF-03357 promoted SK-OV-3 cell (an ovarian cancer derived cell line) proliferation, migration and invasion via downregulating its target gene Homeobox-containing protein 1 (HMBOX1) which was a transcription factor belonging to the hepatocyte nuclear factor family (Zhang et al., 2019a). The gene discussed is HMBOX1; the disease is ovarian carcinoma.