The recent study from Xu et al. (Xu et al., 2022) demonstrated the relationship between YTHDF2 expression and the activation of mTOR/AKT signaling pathway, and showed that the up-regulation of YTHDF2 induced the expression of mTOR mRNA and exacerbated the development of lung squamous cell carcinoma. This evidence concerns the gene YTHDF2 and squamous cell lung carcinoma.