The most common histological features that we observed in our patients with DLE were epidermal atrophy, periadnexal infiltrates, lymphocytic infiltrates, histoplasmacytic infiltrates, follicular plugging and basement membrane thickening, whereas the less common features were loss of sebaceous glands and hair follicles, flattening of rete ridges, dermal edema, dermal mucin, vacuolar interface changes, perifollicular infiltrates and fibrosis and pigment incontinence. The gene discussed is MUC5AC; the disease is discoid lupus erythematosus.