The present meta-analysis has found that the genes associated with worst OS in CRC were β-catenin (cytoplasmic, membranous, and nuclear overexpression), APC (mutant type), Tp53 (mutated), SMAD-3 and SMAD-4 (loss of expression), and Cyclin D1 (high). This evidence concerns the gene SMAD3 and colorectal carcinoma.