Moreover, Lei et al. [42] used mRNA encoding interleukin 15 (IL-15) as a therapeutic gene; in the orthotopic CT26 colon cancer model, intraperitoneal and intravenous administration of carrier/mRNA encoding IL-15 could effectively inhibit tumor growth and lung metastasis by inducing systemic antitumor immune response. Here, IL15 is linked to malignant colon neoplasm.