EPHA2 and ovarian carcinoma: In two researches, DOPC liposomes involving miR-506 mimics which is a regulator of DNA damage response, and epithelial-mesenchymal transition (EMT) phenotype [36] or miR-520d-3p mimics which target the Ephrin type-A receptor 2 (EPHA2) and EPHB2 oncogenes [37] were delivered to orthotopic mouse models of ovarian cancer, suppression of ephrin signaling by miR-520d-3p resulted in remarkable tumor suppression and reduced expression in the respective mRNA targets in vivo.