Conversely, Cori treatment remarkably inhibited HFD-induced increase of fasting blood glucose and insulin concentrations, and strongly reversed the HOMA-IR value (decreased by 1.54 in HCR-L group and 2.23 in HCR-H group) (Figures 3A–C), exerting its ameliorating effects against insulin resistance. This evidence concerns the gene INS and Insulin resistance.