MPO and androgen insensitivity syndrome: Combining the existing studies on neutrophils and lymphocytes in AIS, we suggest that inflammatory substances (ROS, MPO, NE, etc.)released by neutrophils at different stages of AIS may be involved in the development of PSCI by causing hypoperfusion, BBB destruction, brain parenchymal damage, and reduced neovascularization, affecting the structural integrity of the neurovascular unit (5, 6, 20–23).