Wang's team reported that neuronal miR-124 is significantly increased in the hippocampus of TG2576 mice, and that miR-124/PTPN1 pathway is a key mediator of synaptic dysfunction and memory loss in AD, thus miR-124 / PTPN1 pathway can be considered as a promising new therapeutic target for patients with AD (22). Here, PTPN1 is linked to Alzheimer disease.