Five hub genes were identified, namely, ATP2A2, ATP6V1D, CAP2, SYNJ1, and GHITM. A logistic regression model was constructed and applied to perform a comprehensive evaluation of their ability to predict AD and find other AD datasets (gene expression datasets in hippocampus brain regions) in order to validate the diagnostic value of the model. The gene discussed is ATP6V1D; the disease is Alzheimer disease.