PRICKLE1 and hepatocellular carcinoma: The HCC-promoting role of EZH2 stems from its regulation on epigenetic silencing of signal transducer and activator of transcription 3 (STAT3), TGF-beta, and Wnt pathway via inhibitors, such as axis inhibition protein 2 (AXIN2) and prickle planar cell polarity protein 1 (PRICKLE1) [8–10].