As a gene encoding member of the Like-Smith (LSM) family of RNA-binding proteins, LSM2 has not been investigated extensively, but one other member in the LSM family, LSM1, was found to be highly related to “Chemoresistance pathways under the mediation of constitutive activation of PI3K pathway and BCL-2 in SCLC” and “IGF-1 receptor/EGFR cooperation in LC,” suggesting a potential role in LC tumorigenesis [30]. Here, LSM1 is linked to laryngotracheoesophageal cleft.