CLU and cancer: In CRC patients, increased expression of five isoforms in the 40-kDa band in the FI fraction and one isoform in the FII fraction was observed, while the isoforms present in the 40-kDa band probably corresponded to the isoform detected by Pucci et al., who observed increased expression of cytoplasmic glycosylated CLU in the advanced stage of cancer with metastases to the lymph nodes [90].