A study with the use of highly invasive Caki-1 human RCC cells with expression shRNA of clusterin, targeting clusterin (Caki-1/clusterin shRNA), documented that clusterin significantly intensifies the activity of S100A4, one of the members of the S100 proteins family occurring in human RCC, which positively affects tumor growth and invasion. The gene discussed is S100A4; the disease is renal cell carcinoma.