In addition, it was noted that a reduction of expression of clusterin β1,4-triantennary N-glycans in HCC patients was accompanied by an increase in the expression of biantennary N-glycans [103, 104], which may have been caused by decreased expression of N-acetylglucosamine transferase IV, an enzyme which initiates the formation of an additional third branch on the biantennary glycan, resulting in the formation of triantennary glycan [105]. This evidence concerns the gene CLU and hepatocellular carcinoma.