As the study performed by Gbormittah et al. [115] also documented decreased expression of core-fucosylated CLU glycans in the blood plasma of patients with ccRCC, the question arises whether ccRCC cells directly produce altered clusterin with reduced fucosylation or whether the observed changes in CLU fucosylation are a secondary effect of the influence of the tumor microenvironment [115]. Here, CLU is linked to nonpapillary renal cell carcinoma.