NFKB1 and Familial prostate cancer: It was found that DADS reduces the rate of survival of androgen-independent prostate cancer cells by modulating the expression of the IGF system, resulting in the inhibition of Akt phosphorylation, and consequently inhibiting cell cycle survival and progression by reducing the expression of NF-kB, cyclin D1, and antiapoptotic Bcl-2 molecules while enhancing the expression of proapoptotic signaling molecules (Bax and Bad) which trigger apoptosis (Arunkumar et al., 2012).