Overexpression of ATP binding box (ABC) transporters is a major cause of multidrug resistance (MDR) (Wu and Fu, 2018) For example, Heme oxygenase 1 (HMOX1) reduces the sensitivity of HCC cells to sorafenib via regulation of the expression of ABC transporters (Zhu et al., 2022). Here, HMOX1 is linked to hepatocellular carcinoma.