Overexpression of ATP binding box (ABC) transporters is a major cause of multidrug resistance (MDR) (Wu and Fu, 2018) For example, Heme oxygenase 1 (HMOX1) reduces the sensitivity of HCC cells to sorafenib via regulation of the expression of ABC transporters (Zhu et al., 2022). This evidence concerns the gene ABCG2 and hepatocellular carcinoma.