Enrichment analysis of these 430 differential genes through the Metascape online database showed that these genes were mainly enriched in unsaturated fatty acid biosynthetic process, positive regulation of receptor signaling pathway via JAK-STAT, carbohydrate metabolic processing, protein processing in the endoplasmic reticulum, and prion diseases (Figures 3A, B). This evidence concerns the gene SOAT1 and prion disease.