SLC6A14 (ATB0,+) that broadly accepts large neutral amino acids, as well as SLC38A2 (SNAT2), SLC38A3 (SNAT3) and SLC38A7 (SNAT7) that accept some large neutral amino acids such as His, Met and Leu are known to be upregulated in certain types of cancers.8 The gene discussed is SLC38A3; the disease is cancer.