Just as our schematic diagram showed that ox‐LDL is taken up by macrophages, induces macrophages to become foam cells and release exosomes that contain high levels of miR‐4532, which are taken up by endothelial cells and inhibit SP1 expression, while activating NF‐κB P65 signalling, to promote ICAM‐1, VCAM‐1 expression, leading to endothelial dysfunction, and forming a vicious cycle. This evidence concerns the gene SP1 and endothelial dysfunction.