Mechanistically, tumour‐derived HMGB1 induces the production of type I IFNs in dendritic cells via the TLR4‐MyD88 pathway, and tumour‐derived DNA activates the cGAS/STING pathway to drive the expression of type I IFNs through chaperoning HMGB1, autophagosome, exosome, LL37 or CLEC9A into dendritic cells.44 This evidence concerns the gene TLR4 and neoplasm.