The four key genes, IFIT3, XAF1, RSAD2, and MX1, in the normal and HF groups, are shown in Fig. 8A. Wilcoxon test results indicated that IFIT3, MX1, and RSAD2 were highly expressed in the HF group of the GSE76701 dataset, and the gene expression trends were completely consistent with those in the GSE57338 dataset. This evidence concerns the gene XAF1 and hydrops fetalis.