NFKB1 and hyperinsulinism: Interestingly, administration of low-dose SPL attenuated insulin resistance (Fig. 1a), hyperinsulinemia (Fig. 1b) and hyperandrogenism (Fig. 1c) with corresponding decrease in adipose tissue inflammation (NF-κB, TNF-α and IL-6) (Fig. 4) and oxidative stress as well as improvement in antioxidant capacity (Fig. 3) and adipose lipid metabolism (Fig. 2) in PCOS animals compared with untreated PCOS group.