G6PD and polycystic ovary syndrome: Moreover, the present results also demonstrated that PCOS is associated with elevated levels of adipose lipid peroxidation (MDA) (Fig. 3a) which further led to a depletion in antioxidant capacity as revealed by decreased GSH- and G6PD-dependent antioxidant defense (Fig. 3b and c), promoting oxidative stress in PCOS animals compared with control.