The results in addition showed insulin resistance, hyperinsulinemia, hyperandrogenism and oxidative stress as well as a significant increase in inflammatory biomarkers (NF-kB/TNF- and IL-6), with a significant decrease in TG, TC, FFA, GSH and G6PD in the adipose tissue of PCOS animals. The gene discussed is NFKB1; the disease is Hyperinsulinemia.