Similarly, obesity, type 2 diabetes mellitus, and other metabolic abnormalities are associated with activation of MR in the adipose tissue [19], while MR signaling is also involved in the normal physiological differentiation and maturation of adipocyte and enhanced activation of MRs contributes to insulin resistance, oxidative stress, pro-inflammatory adipokine and dysregulation of adipocyte autophagy as well as tissue apoptosis [19]. The gene discussed is NR3C2; the disease is obesity due to melanocortin 4 receptor deficiency.