PGP and cancer: And the content of hsa_circ_0000098 was higher in DOX-resistant patients (Fig. 4O).The findings indicated that dysregulation of the circ_0000098/miR-383/MCUR1 signaling pathway leads to P-gp overexpression and elevated ATP levels, both of which may promote anti-cancer drug efflux and chemoresistance in HCC.