In another study, Konstantinopoulos et al. showed that, for patients who lack a BRCA mutation and have platinum-resistant ovarian carcinoma, the combination of an anti-PD-1 antibody and niraparib (ORR, 19%) appears to improve efficacy when compared with a single-agent PARP inhibitor (ORR, about 5%) or an anti-PD-1 antibody (ORR, 4–10%) [125]. Here, PDCD1 is linked to ovarian carcinoma.