The different phenotypic features activated by AQP4 aggregation/disaggregation state in glioma cells prompted us to hypothesize that different signal cascades could be transferred, via EVs, to surrounding tumour cells from metastatic or apoptotic glioma cells expressing AQP4-tetramers or AQP4-OAPs, respectively. The gene discussed is AQP4; the disease is neoplasm.