According to a previous knock‐out (KO) study, TNF‐α KO mice and TNFR1 KO mice were completely resistant to LPS/D‐gal‐induced acute hepatitis, whereas TNFR2‐deficient mice were susceptible,19 which demonstrated this model is wholly dependent on the TNF‐α/TNFR1 death signalling pathway. This evidence concerns the gene TNFRSF1A and Acute hepatitis.