We suggest that the effect of Ninj1 blocking peptide on TNF‐α/TNFR1‐induced cell death be comprehensively investigated to verify the therapeutic potential of Ninj1 blocking peptide targeting hepatocytes and that studies also be conducted to elucidate the molecular mechanism responsible for TNF‐α/TNFR1 complex II signal regulation by Ninj1 to determine whether Ninj1 is a proper therapeutic target and to develop therapeutic strategies that address liver diseases including ALF. The gene discussed is TNFRSF1A; the disease is liver disorder.