ROC analysis demonstrated a cut-off value of 69.0 kU/L for serum T-IgE (area under curve [AUC]—ROC 0.705; sensitivity 81.3%; specificity 58.6%), and 0.35 × 109/L of blood eosinophil count (AUC-ROC 0.685; sensitivity 57.5%; specificity 72.9%) were optimal for determination of comorbid asthma in patients with CRSwNP (Fig. 2). Here, IGHE is linked to chronic rhinosinusitis with nasal polyps.