The finding that despite greater topical corticosteroids and leukotriene receptor antagonist use by patients with CRSwNP and comorbid asthma, the levels of eosinophils and IgE were found to be significantly higher in these patients than in CRSwNP patients without asthma, suggests that the influence of greater medication use also needs to be taken into consideration and these findings need to be confirmed in prospective multicentre studies with large sample size in the future. Here, IGHE is linked to chronic rhinosinusitis with nasal polyps.