This demonstrated that female gender (Odds ratio [OR] = 3.08, P = 0.005), history of allergic rhinitis (OR = 3.087, P = 0.008), levels of serum T-IgE (OR = 1.002, P = 0.012) and blood eosinophil count (OR = 28.845, P < 0.001) were found to be independent factors associated with asthma comorbidity in patients with CRSwNP (Table 4). The gene discussed is IGHE; the disease is chronic rhinosinusitis with nasal polyps.