APOE and Alzheimer disease: To further investigate a possible biological role of European vs. non-European APOE alleles in AD-neuropathology scores and cognitive abilities (CDR-SOB), we re-run regressions in a subgroup of 309 individuals stratified by their APOE status (APOE4+ and APOE4−) and local ancestry (EUR vs. non-EUR), either adjusting or not for global ancestry (Fig. 1).