Additionally, when adjusted for age, DRE, and total PSA levels, the urine microRNA model, uCaP had similar accuracy to predict Grade group 2 or higher prostate cancer in TRUS biopsy as the 4Kscore in patients with available uCaP score (AUC = 0.759, 95% CI: 0.680, 0.839; AUC = 0.758 95% CI: 0.682, 0.834; respectively). The gene discussed is KLK3; the disease is prostate cancer.