CHRNA7 and Angelman syndrome: The five most frequent syndromes were 22q11.2 deletion (14.6%; MIM#188400); 15q13.3 reciprocal duplication encompassing only the CHRNA7 gene16 (6.6%); 16p11.2 deletion (5%, MIM#611913); 15q11.2 deletion (4.8%; MIM#615656); and Prader-Willi/Angelman syndrome (4.6%; MIM#176270/105830, respectively).