We detected recurrent frameshift deletions in TGFBR2 (c.374delA) and IRF2BPL (c.224_305del and c.225_303del) in ESCC, which were verified in different studies located near the N-terminal of the coding region, indicated their tumor-suppressing functions in ESCC. The gene discussed is TGFBR2; the disease is neoplasm.