NOTCH1 and esophageal squamous cell carcinoma: Notably, the percentage of NOTCH1 alterations was steadily accumulated with increased diagnostic age of ESCC (6.2%, 10.8%, 12.4%, 15.9%, 20.2%, and 27.3% in groups of ≤40 years, 41–50 years, 51–60 years, 61–70 years, 71–80 years, and a 80 years, respectively, p < 0.001 Fig. 6b).