These genes are involved in various frailty-related outcomes, including different types of cancer (i.e., HDAC4, CASP9, NFE2L3, RILP, STK40, HAO2, SNX20, MRTO4, EMILIN3, P4HA3), cardiovascular disease (i.e., HDAC4, CASP9, SARS), diabetes mellitus (i.e., RPL36AL, SARS), and Alzheimer’s Disease (i.e., RPL36AL). The gene discussed is NFE2L3; the disease is cancer.