These genes are involved in various frailty-related outcomes, including different types of cancer (i.e., HDAC4, CASP9, NFE2L3, RILP, STK40, HAO2, SNX20, MRTO4, EMILIN3, P4HA3), cardiovascular disease (i.e., HDAC4, CASP9, SARS), diabetes mellitus (i.e., RPL36AL, SARS), and Alzheimer’s Disease (i.e., RPL36AL). The gene discussed is RPL36AL; the disease is early-onset autosomal dominant Alzheimer disease.