These genes are involved in various frailty-related outcomes, including different types of cancer (i.e., HDAC4, CASP9, NFE2L3, RILP, STK40, HAO2, SNX20, MRTO4, EMILIN3, P4HA3), cardiovascular disease (i.e., HDAC4, CASP9, SARS), diabetes mellitus (i.e., RPL36AL, SARS), and Alzheimer’s Disease (i.e., RPL36AL). Here, P4HA3 is linked to early-onset autosomal dominant Alzheimer disease.