Activation of latent extracellular TGFβ requires physical interaction with integrin αvβ6 or integrin αvβ8, and loss of either TGFβ signalling on T cells, or ITGΒ8 expression by hematopoietic cells, leads to impaired pTreg differentiation and development of autoimmunity and colitis42,43. The gene discussed is TGFB1; the disease is Autoimmunity.